著者プロフィール

原 正彦(はら まさひこ)
1981年 兵庫県宝塚市生まれ
1996年 兵庫県立宝塚西高等学校
1999年 島根大学医学部医学科(平成17年卒業)
2005年 神戸赤十字病院(初期研修)
2007年 大阪労災病院(後期研修)
2010年 大阪大学医学部付属病院 循環器内科
2011年 大阪大学大学院医学系研究科 循環器内科学(大学院生)
2015年 大阪大学医学部附属病院 未来医療開発部(特任研究員)
2016年 一般社団法人日本臨床研究学会 代表理事/大阪市立大学医学部附属病院 循環器内科 客員研究員
循環器専門医、認定内科医
TOEIC 855点  
                         

受賞歴

計 10演題(Young Investigators Award 9演題)

10.
American Heart Association Annual Scientific Sessions 2015 Cardiovascular Disease in the Young Early Career Investigator Award Finalist (honorable mention)(2015年11月8日)
9.
International Heart Journal Ueda Award 最優秀論文賞(2015年9月1日)
8.
American Heart Association Quality of Care and Outcomes Research Scientific Sessions 2015 Young Investigator Award Finalist (honorable mention)(2015年4月29日)
7.
American College of Cardiology Annual Scientific Sessions 2014 Cardiovascular Health Outcomes and Population Genetics Young Investigators Award Finalist(honorable mention)(2014年3月31日)。
6.
American Heart Association Annual Scientific Sessions 2013 Elizabeth Barrett-Connor Research Award for Young Investigators in Training Finalist(honorable mention)(2013年11月17日)
5.
第61回日本心臓病学会総会 Young Investigators Award 最優秀演題賞(2013年9月20日)
4.
第33回心筋梗塞研究会 Young Investigators Award 最優秀演題賞(2013年7月6日)
3.
第49回日本循環器予防学会総会 Young Investigators Award 最優秀演題賞(2013年6月14日)
2.
第16回日本心不全学会総会 Young Investigators Award 優秀演題賞(2012年12月2日)
1.
第111回日本循環器学会近畿地方会 Young Investigators Award 優秀演題賞(2011年6月25日)



〜その他過去の主な発表〜
American Heart Association (AHA) 総会 6演題(Oral 5演題, Poster 1演題)
American College of Cardiology (ACC) 総会 2演題(Oral 2演題)
European Society of Cardiology (ESC) 総会 2演題(Poster 2演題)
日本循環器学会総会 7演題(Plenary session 1演題、Oral 4演題、Poster 2演題)

英字論文

計 47編(筆頭著者 20編、2nd or Corresponding 12編)

47.
Mizutani K, Hara M, Iwata S, Murakami T, Shibata T, Yoshiyama M, Naganuma T, Yamanaka F, Higashimori A, Tada N, Takagi K, Araki M, Ueno H, Tabata M, Shirai S, Watanabe Y, Yamamoto M, Hayashida K. Elevation of B-type natriuretic peptide at discharge is associated with 2-year mortality after transcatheter aortic valve replacement in patients with severe aortic stenosis: insights from a multicenter prospective OCEAN-TAVI (Optimized Transcatheter Valvular Intervention-Transcatheter Aortic Valve Implantation) registry. J Am Heart Assoc. 2017 in press.

46.
Kaneko H, Hara M, Mizutani K, Yoshiyama M, Yokoi K, Kabata D, Shintani A, Kitamura T. Improving outcomes of witnessed out-of-hospital cardiac arrest after implementation of international liaison committee on resuscitation (ILCOR) 2010 consensus: a nationwide prospective observational population-based study. J Am Heart Assoc. 2017 in press.

45.
Fujii T, Matsuyama T, Takeuchi J, Hara M, Kitamura T, Yamauchi-Takihara K. Women among first authors in Japanese cardiovascular journals: an observational study. Int Heart J. 2017 in press.

44.
Mizutani M, Takami A, Hara M, Mizuno S, Yanada M, Chou T, Uchiyama H, Ohashi K, Miyamoto T, Ozawa Y, Imataki O, Kobayashi N, Uchida N, Kanamori H, Kamimura T, Eto T, Onizuka M, Tanaka J, Atsuta Y, Yano S. Comparison of autologous and unrelated transplants for cytogenetically normal acute myeloid leukemia. Biol Blood Marrow Transplant. 2017 in press.

43.
Shimomura Y, Hara M, Hashimoto H, Ishikawa T. Elevated bone marrow eosinophil count is associated with high incidence of severe acute graft versus host disease after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2017 [Epub ahead of print].

42.
Yokoi K, Hara M, Ueda Y, Sumitsuji S, Awata M, Salah YK, Kabata D, Shintani A, Sakata Y. Ideal guiding catheter position during bilaterally engaged percutaneous coronary intervention. Am J Cardiol. 2017;119:1518-1524.

41.
Fujino A, Otsuji S, Hasegawa K, Arita T, Takiuchi S, Fujii K, Yabuki M, Ibuki M, Nagayama S, Ishibuchi K, Kashiyama T, Ishii R, Tamaru Y, Yamamoto W, Hara M, Higashino Y. Accuracy of J-CTO score derived from computed tomography versus angiography to predict successful percutaneous coronary intervention. JACC Cardiovasc Imaging 2017 [Epub ahead of print].

40.
Ishikawa H, Hara M, Ryuge M, Takafuji J, Youmoto M, Akira M, Nagasaka Y, Kabata D, Yamamoto K, Shintani A. Efficacy and safety of super-selective bronchial artery coil embolization for hemoptysis: a single center retrospective observational study. BMJ Open 2017;7:e014805.

39.
Mizutani K, Hara M, Ishikawa H, Nishimura S, Ito A, Iwata S, Takahashi Y, Sugioka K, Murakami T, Shibata T, Yoshiyama M. Safety and efficacy of simultaneous biplane mode of 3-dimensional transesophageal echocardiography-guided antegrade multiple-inflation balloon aortic valvuloplasty in patients with severe aortic stenosis. Circ J. 2017;81:748-754.

38.
Hara M, Hayashi K, Kitamura T. Outcomes differ by first documented rhythm after witnessed out-of-hospital cardiac arrest in children; an observational study with prospective nationwide population-based cohort database in Japan. Eur Heart J Qual Care Clin Outcomes 2017;3:83-92.

37.
Ichiba T, Hara M, Yunoki K, Urashima M, Harano M, Naitou H, Yamamoto K, Shintani A. Baseline disease is more important predictor of intestinal necrosis than CT findings in patients with acute mesenteric ischemia. Am J Emerg Med 2016;34:2261-2265.

36.
Hara M, Sakata Y, Nakatani D, Suna S, Nishino M, Sato H, Kitamura T, Nanto S, Hori M, Komuro I, on behalf of the OACIS Investigators. Impact of coronary collaterals on in-hospital and 5-year mortality after ST-elevation myocardial infarction in the contemporary percutaneous coronary intervention era: a prospective observational study. BMJ Open. 2016;6:e011105.

35.
Ichiba T, Hara M, Yunoki K, Urashima M, Naitou H. Impact of noninvasive conservative medical treatment for symptomatic isolated celiac artery dissection. Circ J. 2016;80:1445-1451.

34.
Kinoshita T, Yoshiya K, Fujimoto Y, Kajikawa R, Kiguchi T, Hara M, Wakayama A, Yoshimine T. Decompressive craniectomy in conjunction with evacuation of intracranial hemorrhagic lesions is associated with worse outcomes in elderly patients with traumatic brain injury: a propensity score analysis. World Neurosurg. 2016;89:187-192.

33.
Mizutani M, Hara M, Fujita H, Aoki J, Kanamori H, Ohashi K, Usuki K, Fukuda T, Chou T, Tanaka J, Atsuta Y, Takami A. Comparable outcomes between autologous and allogeneic transplant for adult Q2 acute myeloid leukemia in first CR. Bone Marrow Transplant. 2016;51:645-653.

32.
Kagiyama N, Toki M, Hara M, Fukuda S, Aritaka S, Miki T, Ohara M, Hayashida A, Hirohata A, Yamamoto K, Yoshida K. Efficacy and accuracy of novel automated mitral valve quantification: Three-dimensional transesophageal echocardiographic study. Echocardiography. 2016;33:756-763.

31.
Nishino M, Okamoto N, Tanaka A, Mori N, Hara M, Yano M, Makino N, Egami Y, Shutta R, Tanouchi J. Different risk factors for bleeding and discontinuation between dabigatran and rivaroxaban. J Cardiol. 2016;68:156-160.

30.
Hara M, Sakata Y, Nakatani D, Suna S, Nishino M, Sato H, Kitamura T, Nanto S, Hamasaki T, Hori M, Komuro I, on behalf of the OACIS Investigators. Subclinical elevation of high-sensitive troponin T levels at the convalescent stage is associated with increased 5-year mortality after ST-elevation myocardial infarction. J Cardiol. 2016;67:314-320.

29.
Hara M, Hayashi K, Hikoso S, Sakata Y, Kitamura T. Different impacts of time from collapse to first cardiopulmonary resuscitation on outcomes after witnessed out-of-hospital cardiac arrest in adults. Circ Cardiovasc Qual Outcomes. 2015;8:277-284.

28.
Nakamura D, Lee Y, Yoshimura T, Taniike M, Makino N, Kato H, Egami Y, Shutta R, Tanouchi J, Yamada Y, Hara M, Sakata Y, Hamasaki T, Nishino M. Different serial changes in the neointimal condition of sirolimus-eluting stents and paclitaxel-eluting stents:an optical coherence tomographic study. Eurointervention. EuroIntervention. 2014;10:924-933.

27.
Hara M. Re: Angiotensin receptor blocker in patients with ST segment elevation myocardial infarction with preserved left ventricular systolic function: prospective cohort study. BMJ 2014;349:g6650. (Link)

26.
Hara M, Sakata Y, Nakatani D, Suna S, Usami M, Matsumoto S, Ozaki K, Nishino M, Sato H, Kitamura T, Nanto S, Hamasaki T, Tanaka T, Hori M, Komuro I, on behalf of the OACIS Investigators. Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 C risk allele in the contemporary percutaneous coronary intervention era: a prospective observational study. BMJ Open 2014;4:e005438.

25.
Hara M, Sakata Y, Nakatani D, Suna S, Usami M, Matsumoto S, Sugitani T, Nishino M, Sato H, Kitamura T, Nanto S, Hamasaki T, Hori M, Komuro I, on behalf of the OACIS Investigators. Comparison of 5-year survival after acute myocardial infarction using angiotensin converting enzyme inhibitor versus angiotensin II receptor blocker. Am J Cardiol. 2014;114:1-8.

24.
Edahiro R, Sakata Y, Nakatani D, Suna S, Usami M, Matsumoto S, Hara M, Kitamura T, Sato H, Yamashita S, Nanto S, Hikoso S, Sakata Y, Hori M, Hamasaki T, Komuro I, on behalf of the OACIS Investigators. Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: a prospective observational study in Japan. BMJ Open. 2014;4:e005067.

23.
Hara M
, Sakata Y, Nakatani D, Suna S, Usami M, Matsumoto S, Sugitani T, Ozaki K, Nishino M, Sato H, Kitamura T, Nanto S, Hamasaki T, Tanaka T, Hori M, Komuro I, on behalf of the OACIS Investigators. Renin-angiotensin-aldosterone system polymorphisms and five-year mortality in survivors of acute myocardial infarction: a report from the Osaka Acute Coronary Insufficiency Study. Int Heart J. 2014;55:190-196.

22.
Usami M, Sakata Y, Nakatani D, Suna S, Matsumoto S, Hara M, Kitamura T, Ueda Y, Iwakura K, Sato H, Hamasaki T, Nanto S, Hori M, Komuro I. Clinical impact of acute hyperglycemia on development of diabetes mellitus in non-diabetic patients with acute myocardial infarction. J Cardiol. 2014;63:274-280.

21.
Kitamura T, Sakata Y, Nakatani D, Suna S, Usami M, Matsumoto S, Hara M, Hamasaki T, Nanto S, Sato H, Hori M, Iso H, Komuro I. Living alone and risk of cardiovascular events following discharge after acute myocardial infarction in Japan. J Cardiol. 2013;62:257-262.

20.
Matsumoto S, Sakata Y, Nakatani D, Suna S, Usami M, Hara M, Kitamura T, Hamasaki T, Nanto S, Kawahara Y, Komuro I. Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction. Circ Res. 2013;113:322-326.

19.
Hara M, Sakata Y. Polyunsaturated fatty acids in heart failure. Circ J. 2013;77:1917-1918.

18.
Hara M, Sakata Y, Nakatani D, Suna S, Usami M, Matsumoto S, Hamasaki T, Doi Y, Nishino M, Sato H, Kitamura T, Nanto S, Hori M, Komuro I; for the Osaka Acute Coronary Insufficiency Study (OACIS) Investigators. Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction. Circ J. 2013;77:153-162.

17.
Suna S, Sakata Y, Nakatani D, Okuda K, Shimizu M, Usami M, Matsumoto S, Hara M, Ozaki K, Mizuno H, Minamino T, Takashima S, Nishino M, Matsumura Y, Takeda H, Tanaka T, Sato H, Hori M, Komuro I. Decreased mortality associated with statin treatment in patients with acute myocardial infarction and lymphotoxin-alpha C804A polymorphism. Atherosclerosis. 2013;227:373-379.

16.
Matsumoto S, Nakatani D, Sakata Y, Suna S, Shimizu M, Usami M, Hara M, Sumitsuji S, Nanto S, Sasaki T, Hamasaki T, Sato H, Hori M, Komuro I; Osaka Acute Coronary Insufficiency Study (OACIS) Group. Elevated serum heart-type Fatty Acid-binding protein in the convalescent stage predicts long-term outcome in patients surviving acute myocardial infarction. Circ J. 2013;77:1026-1032.

15.
Nakatani D, Sakata Y, Suna S, Usami M, Matsumoto S, Shimizu M, Hara M, Uematsu M, Fukunami M, Hamasaki T, Sato H, Hori M, Komuro I; Osaka Acute Coronary Insufficiency Study (OACIS) Investigators. Impact of beta blockade therapy on long-term mortality after ST-segment elevation acute myocardial infarction in the percutaneous coronary intervention era. Am J Cardiol. 2013;111:457-464.

14.
Sakata Y, Nakatani D, Shimizu M, Suna S, Usami M, Matsumoto S, Hara M, Sumitsuji S, Kawano S, Iwakura K, Hamasaki T, Sato H, Nanto S, Hori M, Komuro I. Oral treatment with nicorandil at discharge is associated with reduced mortality after acute myocardial infarction. J Cardiol. 2012;59:14-21.

13.(2年目研修医指導)
Muratsu J, Hara M, Mizote I, Asano Y, Sakata Y, Saito S, Matsumiya G, Sawa Y, Komuro I. The impact of cardiac resynchronyzation therapy in an end-stage heart failure patient with a left ventricular assist device as a bridge to recovary. A case report. Int Heart J. 2011;52:246-247.

12.(1年目研修医指導)
Katsuragi S, Hara M, Mizote I, Sakata Y, Yamauchi-Takihara K, Komuro I. Adjunctive tadalafil therapy for managing pulmonary hypertension in a patient with obesity hypoventilation syndrome. J Cardiol Cases 2011;4:e126-128.

11.
Hara M, Mizuno H, Mizote I, Nakatani D, Asano Y, Sakata Y, Nanto S, Komuro I. Clinical impact of off-label cardiac resynchronization therapy in end-stage heart failure patients on continuous intravenous inotrope. Clin Cardiol. 2011;34:714-720.

10.
Hara M, Nishino M, Taniike M, Makino N, Kato H, Egami Y, Shutta R, Tanouchi J, Hunatsu T, Taniguchi K, Yamada Y. Impact of 64 multi-detector computed tomography for the evaluation of aortic paraprosthetic regurgitation. J Cardiol. 2011;58:294-299.

9.
Hara M, Nishino M, Taniike M, Makino N, Kato H, Egami Y, Shutta R, Tanouchi J, Yamada Y. Serial angioscopic evaluation of neointimal coverage and incidence of thrombus formation after Paclitaxel-eluting stent implantation; comarison between 6- and 18-month follow-up. Clin Cardiol. 2011;34:322-326.

8.
Hara M, Mizote I, Nakaoka Y, Tanaka H, Asano Y, Sakata Y, Komuro I. A case of non-cardiogenic acute pulmonary edema in a patient with POEMS syndrome-associated pulmonary arterial hypertension. Ann Hematol. 2011;90:489-490.

7.
Hara M, Nishino M, Taniike M, Makino N, Kato H, Egami Y, Shutta R, Yamaguchi H, Tanouchi J, Yamada Y. Chronic effect of right ventricular pacing on left ventricular rotational synchrony in patients with complete atrioventricular block. Echocardiography. 2011;28:69-75.

6.(1年目研修医指導)
Shimomura Y, Hara M, Mizote I, Nakaoka Y, Tanaka H, Asano Y, Sakata Y, Komuro I. Sildenafil and steroid therapy effectively improved POEMS syndrome-associated pulmonary arterial hypertension. Int J Hematol. 2010;92:774-776.

5.
Hara M, Nishino M, Taniike M, Makino N, Kato H, Egami Y, Shutta R, Yamaguchi H, Tanouchi J, Yamada Y. High incidence of thrombus formation at 18 months after paclitaxel-eluting stent implantation: angioscopic comparison with sirolimus-eluting stent. Am Heart J. 2010;159:905-910.

4.
Hara M, Nishino M, Yamada Y. Cardiac tumor-like mass in a patient with systemic vasculitis. J Am Coll Cardiol. 2010;55:1882.

3.
Hara M, Nishino M, Taniike M, Makino N, Kato H, Egami Y, Shutta R, Yamaguchi H, Tanouchi J, Yamada Y. Difference of neointimal formational pattern and incidence of thrombus formation among 3 kinds of stents: an angioscopic study. JACC Cardiovasc Interv. 2010;3:215-220.

2.
Hara M, Nishino M. Impact of intravascular ultrasound for the treatment of calcified infrarenal aortic stenosis: a case report study. Catheter Cardiovasc Interv. 2008;72:867-870.

1.
Hara M, Nishino M, Matsuoka K, Yamada Y. Heavily calcified chronic total occlusion of common iliac artery successfully treated with Tornus microcatheter and rotational atherectomy. J Vasc Surg. 2008;48:758-760.